We are interested in the stage of the HIV-1 virus replication cycle, where the viral particles are assembled from thousands of polyproteins and two molecules of genomic RNA. On the other hand, we also study the opposite process during which the HIV particle undergoes the disassembly or uncoating to release its genomic information. We are interested not only in the structural-functional aspects of these processes, but we also seek for compounds that would inhibit these steps. In addition to human retroviruses, we also study simian virus M-PMV and murine leukemia virus MLV
Grant supports: GAČR 2017-2019, MŠMT: 2018-2021
Collaboration: UCT Prague: Department of Biochemistry and Microbiology, Central laboratories, Department of Chemistry of Natural Compounds, Department of Analytical Chemistry, IOCB CAS, University of Texas in El Paso USA; University of Cambridge UK