- Prof. Michaela Rumlová, PhD (contact person)
- Ivana Křížová, MSc (staff and doctoral student)
- Alžběta Dostálková, MSc (doctoral student)
- Ing. Filip Kaufman, MSc (doctoral student)
The substantial part of our scientific research is devoted to the study of viruses. We investigate retroviruses, i.e. viruses that can reversely transcribe their genetic information from RNA to DNA, and we are focused mainly on one important retroviral member: HIV, a causative agent of AIDS. We are also interested in flaviviruses, especially their representatives such as Dengue virus, tick-borne encephalitis virus, and Zika virus. We study a certain stage in the replication cycle of these viruses, during which hundreds to thousands of copies of viral structural proteins and viral genomic information gather at some specific place within the infected cell, and based on their mutual interactions the assembly of new viral particle is initiated. In order to inhibit these steps and prevent thus the viral infection, our goal is to understand the structural-functional mechanisms of these protein-protein and protein-RNA interactions, which are critical for the formation of the new viral particle.