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Bursar
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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461373 / VAT: CZ60461373
Czech Post certified digital mail code: sp4j9ch
Copyright: UCT Prague 2017
Information provided by the Department of International Relations and the Department of R&D. Technical support by the Computing Centre.
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[nazev] => Department of Biotechnology
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As the Department name indicates, the Department of Biotechnology is engaged in education, science, and consultancy activities in biotechnologies from the chemical, technical, and engineering points of view. The Department's core activities are in brewing, biotechnologies for environmental protection, alternative fuel production, issues of biofilms, and the production of biodetergents and enzymes.
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[obsah] => Our Department offers higher education in fields of traditional as well as modern biotechnologies, e.g. chemical and pharmaceutical industries and environmental protection, and bioengineering. The Department is accredited to provide three-year Bachelor programmes, two-year Master programmes, and Doctoral programmes.
Interested students can participate in scientific and research work at the Department from the outset of their studies.
Given a wide range of contacts in Europe and worldwide, it is possible to apply for study or research fellowships.
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Research focuses on biotechnological processes in their entireties—including the behavior of biological agents; the study of unit operations which are involved in modern biotechnology, including downstream processing; aspects of bioengineering and the modeling and simulation of bioprocesses; the application of biotechnological processes in the food, pharmaceutical, biotechnology and chemical industries; and environmental protection.
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Collaboration with domestic and international industrial and research partners on a wide range of joint projects involving basic and applied research, scaling of technologies and reactors, solution of technological problems by form of grants or cooperation contracts is an essential part of our scientific and research work. An integral part of this cooperation is the involvement of students of all learning levels in such projects to improve their knowledge and skills.
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[obsah] => Since 2021, we have also focused on the study of possible ways of inhibiting the replication of SARS-CoV-2 viral RNA. Since SARS-CoV-2 encodes proteins that are involved in the repair mechanisms of mutations occuring during RNA replication, the use of nucleoside analogs as antivirals for the treatment of COVID-19 is highly restricted. Therefore, we focus on characterizing the potential allosteric inhibition of RNA-dependent RNA polymerase (RdRp) and screening the binding activity of small compounds that exhibit an inhibitory effect. Furthermore, we deal with the in vitro analysis of naturally occurring mutations in RdRp regions, the occurrence of which is related to different SARS-CoV-2 variants reported in the last three years for RdRp cofactors (nsp7, nsp8, and nsp12). Our other target is the exoribonuclease complex responsible for the repair activity of SARS-CoV-2 RNA replication. Inhibition of the activity of this complex, consisting of the exoribonuclease domain and its cofactor, appears as a promising approach to increase the efficacy of RdRp active site inhibitors.
Source: Glaunsinger Lab: Jessica M Tucker, Britt A Glaunsinger et al (Content Experts)
Grant supports: GAČR 2022-2024
Collaboration: Department of Biochemistry and Microbiology UCT Prague, IOCB CAS
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[obsah] => In addition to retroviruses, we also study flaviviruses, especially Dengue virus, tick-borne encephalitis virus, and Zika virus. We are trying to investigate how flaviviral proteins recognize their genomic RNA and select it among many other nucleic acid molecules in the cell. We characterize structural motifs on the genomic RNA and analyze their affinity to flaviviral capsid protein. We also participate in the NMR structural studies of the capsid protein of both Dengue virus and tick-borne encephalitis virus. Our ultimate goal is to develop an in vitro method for testing of inhibitors of the assembly of viral particles and seek for inhibitors that would inhibit this step of flaviviral replication cycle.
Grant support: GAČR 2018-2020
Collaboration: Biology Centre CAS, University of South Bohemia in České Budejovice, IOCB CAS, BIOCEV
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[obsah] => We also study selected human proteins, especially WT1, AKIP1, DHX15, and NMDAR. For their production in bacterial, insect or tissue cells and subsequent isolation and purification, we engineer a broad spectrum of expression vectors. Using directed or alanine-scanning mutagenesis we identify the important amino acid residues or functional domains for their cellular functioning. The biochemical properties of purified proteins are tested using variety of biochemical or structural approaches.
Grant support: TAČR 2019-2020
Collaborations: Institute of Physiology CAS, Motol University Hospital
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[nazev] => Interactions of viral and cellular proteins
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[obsah] => Viruses, as non-cellular organisms, build up only from their genetic information and protein coat, need for their successful replication a broad variety of cellular proteins. By combination of immunochemical and virological techniques, we are currently studying two cellular proteins that are critical to the replication cycle of Mason-Pfizer monkey virus (M-PMV) and HIV-1.
Grant supports: GAČR 2017-2019, MŠMT 2018-2021
Collaboration: Department of Biochemistry and Microbiology UCT Prague, IOCB CAS
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[obsah] => We are interested in the stage of the HIV-1 virus replication cycle, where the viral particles are assembled from thousands of polyproteins and two molecules of genomic RNA. On the other hand, we also study the opposite process during which the HIV particle undergoes the disassembly or uncoating to release its genomic information. We are interested not only in the structural-functional aspects of these processes, but we also seek for compounds that would inhibit these steps. In addition to human retroviruses, we also study simian virus M-PMV and murine leukemia virus MLV
Grant supports: GAČR 2017-2019, MŠMT: 2018-2021
Collaboration: UCT Prague: Department of Biochemistry and Microbiology, Central laboratories, Department of Chemistry of Natural Compounds, Department of Analytical Chemistry, IOCB CAS, University of Texas in El Paso USA; University of Cambridge UK
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